Preferred Label : Xiliertinib;
NCIt synonyms : Theliatinib;
NCIt definition : An orally available, ATP-competitive inhibitor of the epidermal growth factor receptor
(EGFR), with potential antineoplastic activity. Upon oral administration, xiliertinib
binds to and inhibits the activity of EGFR. This prevents EGFR-mediated signaling,
and may lead to both induction of cell death and inhibition of tumor growth in EGFR-overexpressing
cells. EGFR, a receptor tyrosine kinase mutated in many tumor cell types, plays a
key role in tumor cell proliferation and tumor vascularization.;
UNII : 6ZZ3B7NZ0B;
InChIKey : FSXCKIBROURMFT-VGSWGCGISA-N;
CAS number : 1353644-70-8; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 1353644-70-8
alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo
G-SRS /a ;
Molecule name : HMPL 309; HMPL-309;
NCI Metathesaurus CUI : CL971129;
Origin ID : C162552;
UMLS CUI : C5206642;
Semantic type(s)
- concept_is_in_subset
- has_target
