Zinostatin Stimalamer

Preferred Label : Zinostatin Stimalamer;

NCIt synonyms : YM-881;

NCIt definition : A highly lipophilic conjugate protein comprised of the lipophilic antitumor protein, neocarzinostatin (NCS), conjugated with a water-soluble copolymer of styrene-maleic acid (SMA) with potential antineoplastic activity. Upon intra-hepatic arterial administration, zinostatin stimalamer is deposited within tumor tissues, where the NCS moiety induces sequence-specific single and double-stranded breaks via free-radical based mechanisms, resulting in tumor cell death.;

CAS number : 123760-07-6;

Drug name : SMANCS;

Molecule name : YM 881; YM881;

NCI Metathesaurus CUI : CL971120;

Details

Origin ID

C162544;

UMLS CUI

C0071449;

Automatic exact mappings (from CISMeF team)
- eyelids [MeSH Descriptor]
Currated CISMeF NLP mapping
- poly(maleic acid-styrene)neocarzinostatin [MeSH Supplementary Concept]
- poly(maleic acid-styrene)neocarzinostatin [MeSH concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
UMLS correspondences (same concept)
- poly(maleic acid-styrene)neocarzinostatin [MeSH Supplementary Concept]
- poly(maleic acid-styrene)neocarzinostatin [MeSH concept]
concept_is_in_subset
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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