Preferred Label : Anti-BCMA Antibody-drug Conjugate AMG 224;
NCIt related terms : AMG-224;
NCIt definition : An antibody-drug conjugate (ADC) comprised of an anti-human B-cell maturation antigen
(BCMA) immunoglobulin G1 (IgG1) antibody conjugated via the noncleavable linker 4-(N-maleimidomethyl)
cyclohexane-1-carboxylate (MCC), to the cytotoxic maytansine-derivative, DM1, with
potential antineoplastic activity. Upon administration, the monoclonal antibody moiety
of AMG 224 selectively binds to BCMA expressed on the surface of tumor cells. Upon
internalization, the DM1 moiety binds to tubulin, thereby disrupting microtubule assembly/disassembly
dynamics and inhibiting both cell division and proliferation of tumor cells that express
BCMA. BCMA, a receptor for a proliferation-inducing ligand (APRIL) and B-cell activating
factor (BAFF), is a member of the tumor necrosis factor (TNF) receptor superfamily
(TNFRSF)and plays a key role in plasma cell survival; it is found on the surfaces
of plasma cells and overexpressed on malignant plasma cells.;
UNII : Y69B45U0TK;
Molecule name : AMG 224; AMG-224;
NCI Metathesaurus CUI : CL971104;
Origin ID : C162528;
UMLS CUI : C4733482;
Semantic type(s)
- concept_is_in_subset
- has_target
