Preferred Label : Tubulin Polymerization Inhibitor AEZS 112;
NCIt definition : An orally bioavailable small molecule tubulin polymerization inhibitor with potential
antineoplastic activity. Upon oral administration, tubulin polymerization inhibitor
AEZS 112 binds to tubulin and prevents its polymerization in tumor blood vessel endothelial
cells and tumor cells. This blocks the formation of the mitotic spindle and leads
to cell cycle arrest at the G2/M phase. As a result, this agent disrupts the tumor
vasculature and tumor blood flow, deprives tumor cells of nutrients and induces tumor
cell apoptosis. In addition, this agent has a direct cytotoxic effect on tumor cells
by inhibiting tubulin polymerization.;
CAS number : 1214741-69-1; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 1214741-69-1
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G-SRS /a ;
Molecule name : AEZS-112; ZEN 012; AEZS 112; ZEN-012;
NCI Metathesaurus CUI : CL971107;
Origin ID : C162525;
UMLS CUI : C5206623;
Semantic type(s)
- chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
