Preferred Label : Pegylated Deoxycytidine Analogue DFP-14927;
NCIt synonyms : Polymeric Nucleoside Analogue DFP-14927; PEGylated DFP-10917;
NCIt related terms : Nucleoside Analog DFP-10917;
NCIt definition : A pegylated formulation containing DFP-10917, an analogue of the nucleoside deoxycytidine,
with potential antineoplastic activity. Upon administration, the pegylated deoxycytidine
analogue DFP-14927 is incorporated into the DNA of rapidly proliferating cells, such
as tumor cells, and directly inhibits the activity of DNA polymerase, which results
in the inhibition of DNA replication and cell cycle arrest, DNA fragmentation, and
tumor cell apoptosis.;
Molecule name : DFP 14927; DFP-14927;
NCI Metathesaurus CUI : CL970946;
Origin ID : C162508;
UMLS CUI : C5206610;
Semantic type(s)
- concept_is_in_subset
- has_target
