Preferred Label : HPV16 E7-specific HLA-A*02:01-restricted IgG1-Fc Fusion Protein CUE-101;
NCIt synonyms : Anti-HPV16 E7 Fusion Protein CUE-101;
NCIt definition : A fusion protein composed of a human leukocyte antigen (HLA) complex, HLA-A*0201,
with a peptide epitope derived from the human papillomavirus type 16 (HPV16) E7 protein
(amino acid residues 11-20), a reduced affinity human interleukin-2 (IL-2) variant,
and an effector attenuated human immunoglobulin G1 (IgG1) Fc domain, with potential
antineoplastic and immunostimulatory activities. Upon administration, CUE-101 targets
and selectively binds to E7-specific CD8-positive T-cells present in patients with
HPV16-driven malignancies. This may induce the secretion of inflammatory cytokines
such as interferon gamma (IFN gamma) and promote the activation and expansion of tumor-specific
CD8-positive cells, which may lead to T-cell-mediated elimination of tumor cells expressing
the HPV16 E7 antigen. The HPV16 E7 oncoprotein is a cell surface glycoprotein and
tumor-associated antigen (TAA) that is overexpressed in various HPV-associated cancers.;
Molecule name : CUE 101; CUE-101;
NCI Metathesaurus CUI : CL970959;
Origin ID : C162459;
UMLS CUI : C5206571;
Semantic type(s)
- concept_is_in_subset
- has_target
