Oncogene ErbB2

Preferred Label : Oncogene ErbB2;

NCIt synonyms : Oncogene, C-Erb -2; HER-2/NEU; Oncogene, ERBB2; HER -2; Oncogene, C-ErbB-2; Oncogene, NEU;

NCIt definition : Human Oncogene ErbB2 is a mutated variant of ERBB2 Gene, which encodes ERRB2 Receptor Protein Tyrosine Kinase, a 185-kDa type I membrane glycoprotein similar to EGFR that controls cell growth. Ligand binding increases ERBB2 tyrosine phosphorylation. A heterodimer with ERBB3 and ERBB4, p185ERBB2 is an essential component of the heregulin/neuregulin receptor. ERBB2 forms an IL6-dependent complex with IL6R gp130, resulting in ERBB2 tyrosine phosphorylation and MAPK activation. Oncogene ERBB2 disrupts normal cell function.;

GenBank Accession Number : M11730;

Details

Origin ID

C16239;

UMLS CUI

C3853888;

Automatic exact mappings (from CISMeF team)
- Erb-b2 receptor tyrosine kinase 2 [OMIM gene]
- her-2 / neu [medical devices type]
- her-2 / neu [medical devices type]
- her-2/neu [EMDN type]
OMIM relation
- Erb-b2 receptor tyrosine kinase 2 [OMIM gene]
Semantic type(s)
- Gene or Genome [UMLS semantic type]
allele_in_chromosomal_location
- 17q21.1 [NCIt concept]
gene_associated_with_disease
- Adenocarcinoma [NCIt concept]
gene_found_in_organism
- Human [NCIt concept]
gene_is_biomarker_type
- Tumor Marker [NCIt concept]
gene_plays_role_in_process
- Cell Proliferation [NCIt concept]
- Protein Phosphorylation Process [NCIt concept]
- Receptor Signaling [NCIt concept]
- Signal Transduction [NCIt concept]
- Tumorigenesis [NCIt concept]
- Tyrosine Phosphorylation [NCIt concept]

Keyword's position in hierarchy(ies) :

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