Preferred Label : Exatecan Mesylate Anhydrous;
NCIt synonyms : 10H,13H-Benzo(de)pyrano(3',4':6,7)indolizino(1,2-b)quinoline-10,13-dione, 1-Amino-9-ethyl-5-fluoro-1,2,3,9,12,15-hexahydro-9-hydroxy-4-methyl-,
(1S,9S)-, Methanesulfonate (1:1);
NCIt definition : The anhydrous, mesylate salt form of exatecan, a semisynthetic, water-soluble derivative
of camptothecin, with antineoplastic activity. Upon administration, exatecan mesylate
inhibits topoisomerase I activity by stabilizing the cleavable complex between topoisomerase
I and DNA and inhibiting re-ligation of DNA breaks, thereby inhibiting DNA replication
and triggering apoptotic cell death.;
UNII : Y76278R9RJ;
InChIKey : BICYDYDJHSBMFS-GRGFAMGGSA-N;
CAS number : 169869-90-3;
NCI Metathesaurus CUI : CL970851;
Origin ID : C162348;
UMLS CUI : C5206543;
Semantic type(s)
- concept_is_in_subset
- has_free_acid_or_base_form
- is_salt_form_of
