Preferred Label : TRPM8 Agonist D-3263;
NCIt synonyms : Enteric-Coated TRPM8 Agonist D-3263 Hydrochloride;
NCIt related terms : D-3263;
NCIt definition : A small-molecule agonist for transient receptor potential melastatin member 8 (TRPM8
or Trp-p8), with potential antineoplastic activity. Upon administration, TRPM8 agonist
D-3263 targets, binds to and activates TRPM8, which may result in an increase in intracellular
calcium and sodium influx; the disruption of calcium and sodium homeostasis; and the
induction of cell death in TRPM8-expressing tumor cells. This agent may decrease dihydrotestosterone
(DHT) levels, which may contribute to its inhibitory effects on prostate cancer and
benign prostatic hyperplasia (BPH). TRPM8 is a transmembrane calcium channel protein
that is normally expressed in prostate cells and appears to be overexpressed in BPH
and in prostate cancer.;
UNII : 70FBL3TX3E;
CAS number : 947257-66-1;
Molecule name : D-3263; D 3263;
NCI Metathesaurus CUI : CL970854;
Origin ID : C162345;
UMLS CUI : C5206540;
Semantic type(s)
- concept_is_in_subset
