Vascular Disrupting Agent BNC105

Preferred Label : Vascular Disrupting Agent BNC105;

NCIt synonyms : 2-Methyl-7-hydroxy-3-(3,4,5-trimethoxybenzoyl)-6-methoxybenzofuran;

NCIt related terms : BNC-105;

NCIt definition : A vascular disrupting agent (VDA), with potential anti-vascular and antineoplastic activities. Upon administration, vascular disrupting agent BNC105 binds to tubulin and inhibits its polymerization, which results in a blockage of mitotic spindle formation, cell cycle arrest, and disruption of the tumor vasculature. This deprives tumor cells of nutrients and results in tumor cell apoptosis. In addition to its VDA activity, this agent has a direct cytotoxic effect on tumor cells by inhibiting tubulin polymerization.;

UNII : Z3S2Z6H7B0;

InChIKey : RADMJHVVIZTENA-UHFFFAOYSA-N;

CAS number : 945771-74-4;

Molecule name : BNC 105; BNC-105;

NCI Metathesaurus CUI : CL970840;

Details

Origin ID

C162343;

UMLS CUI

C2975137;

Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- BNC 105 [MeSH Supplementary Concept]
- BNC 105 [MeSH concept]
chemical_or_drug_has_mechanism_of_action
- Microtubule Process [NCIt concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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