Preferred Label : Autologous mDC3/8-KRAS Vaccine;
NCIt synonyms : Autologous Peptide-pulsed mDC3/8 KRAS Vaccine;
NCIt definition : An antineoplastic vaccine composed of autologous mature dendritic cells (mDCs) pulsed
with mutant KRAS peptides specific to a patient's tumor mutation and human leukocyte
antigen (HLA) type, with potential immunostimulating and antineoplastic activities.
Upon administration, this vaccine, which is administered as an mDC3 primer, followed
by an mDC8 booster, may elicit a cytotoxic T-cell (CTL) response against cancer cells
expressing certain KRAS mutations. K-RAS, a member of the RAS family of oncogenes,
serves an important role in cell signaling, division and differentiation. Mutation
of K-RAS may induce constitutive signal transduction leading to tumor cell growth,
proliferation, invasion, and metastasis.;
NCI Metathesaurus CUI : CL970895;
Origin ID : C162269;
UMLS CUI : C5206477;
Semantic type(s)
- concept_is_in_subset
- has_target
