Preferred Label : Engineered Human Umbilical Vein Endothelial Cells AB-205;
NCIt synonyms : Engineered HUVEC AB-205; AB-205 Cell Product;
NCIt definition : A population of ex vivo expanded, genetically engineered CD31 (platelet endothelial
cell adhesion molecule; PECAM-1)-positive human umbilical vein endothelial cells (HUVECs)
derived from human umbilical vein tissue, that can be used to enhance the hematopoietic
stem and progenitor cells (HSPCs) transplantation potential and improve blood cell
recovery. Following autologous stem cell transplantation (ASCT) and upon the administration
of the engineered HUVEC AB-205, the endothelial cells secrete angiocrine growth factors
and interact with the HSPCs, thereby forming endothelial cell network structures and
improving engraftment potential. AB-205 also interacts with injured or damaged vascular
niche cells, thereby promoting blood cell recovery and improving tissue regeneration.
This enhances recovery from toxicities related to chemo/radiation regimens.;
Molecule name : AB 205; AB-205;
NCI Metathesaurus CUI : CL970717;
Origin ID : C162248;
UMLS CUI : C5206457;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
