Preferred Label : Furosemide/Digoxin Topical Gel CLS003;
NCIt synonyms : ICVT Product CLS003; Digoxin-Furosemide Topical Gel CLS003;
NCIt definition : A topical ionic contra-viral therapy (ICVT) gel-based formulation that combines furosemide,
a sulfamoylanthranilic acid derivative and loop diuretic, and digoxin, a cardiac glycoside,
with potential antiviral activity. Upon topical administration, furosemide interacts
with the cell membrane ion co-transporter, Na -K -2Cl-co-transporter-1(NKCC1; SLC12A2)
and digoxin reversibly inhibits the sodium/potassium-transporting ATPase, leading
to a decrease in potassium influx. This may prevent the replication of certain DNA
viruses including human papillomavirus (HPV), that rely on potassium for replication.;
Molecule name : CLS 003; CLS-003;
NCI Metathesaurus CUI : CL970783;
Origin ID : C162192;
UMLS CUI : C5206408;
Semantic type(s)
- concept_is_in_subset
