Preferred Label : Microbial Ecosystem Therapeutics-4;
NCIt synonyms : MET 4; MET-4; MET4;
NCIt definition : An orally available formulation consisting of a well-defined mixture of over thirty
intestinal bacteria isolated from a healthy donor stool sample with potential immunomodulatory
effects. Upon administration, the bacteria in microbial ecosystem therapeutics-4 (MET4)
may help maintain adequate colonization of the gastrointestinal (GI) tract and modulate
the composition of the normal microflora. Upon colonization of the GI tract, the probiotic
bacteria form a protective barrier that helps maintain the integrity of the epithelial
barrier. This will interfere with the attachment of pathogenic bacteria and other
harmful substances, prevent inflammation and improve GI function. Additionally, increased
gut microbiota diversity and the presence of certain bacterial genera present in MET4
may improve outcomes following immunotherapy, potentially via certain mucosal and
systemic immune responses induced by the microbiome across the gut barrier.;
NCI Metathesaurus CUI : CL970770;
Origin ID : C162187;
UMLS CUI : C5206405;
Semantic type(s)
- concept_is_in_subset
