Preferred Label : CRTH2 Antagonist ACT-774312;
NCIt synonyms : Prostaglandin D2 Receptor 2 Antagonist ACT-774312;
NCIt related terms : ACT-774312;
NCIt definition : An orally bioavailable, selective antagonist of the chemoattractant receptor-homologous
molecule expressed on T-helper (Th) 2 cells (CRTH2; prostaglandin D2 receptor 2; G-protein
coupled receptor 44), with potential anti-allergic and anti-inflammatory activities.
Upon administration, CRTH2 antagonist ACT-774312 selectively binds to and prevents
the activation of CRTH2 by prostaglandin D2 (PGD2). This may inhibit the recruitment
of eosinophils, basophils, innate lymphoid cells type 2 (ILC2), and Th2 cells, thereby
reducing the number of inflammatory cells within the affected tissue. Additionally,
this may reduce the release of cytokines at the site of allergen entry and block type
2 cytokine-mediated effects such as tissue remodeling. CRTH2, a G-protein-coupled
receptor, is mainly expressed on eosinophils, basophils, macrophages, monocytes, mast
cells, Th2 cells, ILC2 and dendritic cells (DCs).;
UNII : ZV9R9THV2A;
CAS number : 1809863-68-0;
Molecule name : ACT-774312; ACT 774312;
NCI Metathesaurus CUI : CL970398;
Origin ID : C161834;
UMLS CUI : C5206133;
Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
