BR96-Doxorubicin Immunoconjugate

Preferred Label : BR96-Doxorubicin Immunoconjugate;

NCIt synonyms : BR96-DOX immunoconjugate; BR96-Doxorubicin Conjugate; cBR96-Doxorubicin Immunoconjugate; BR96-DOX; BR96-Doxorubicin;

NCIt definition : An antibody-drug conjugate composed of the chimeric monoclonal antibody BR96 chemically linked to the cytotoxic drug doxorubicin. The antibody moiety of BMS-182248-1 binds to Lewis Y, a cell surface antigen expressed on many solid tumor types. Thus, the doxorubicin conjugate is targeted specifically to Lewis Y-expressing tumor cells, where it intercalates with DNA, thereby inhibiting DNA replication and repair, RNA synthesis and protein synthesis. (NCI);

Molecule name : SGN-15; BMS-182248-01;

Details

Origin ID

C1617;

UMLS CUI

C0295525;

Currated CISMeF NLP mapping
- BR96-doxorubicin immunoconjugate [MeSH concept]
- BR96-doxorubicin immunoconjugate [MeSH Supplementary Concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- BR96-doxorubicin immunoconjugate [MeSH concept]
- BR96-doxorubicin immunoconjugate [MeSH Supplementary Concept]
concept_is_in_subset
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
is_component_of_chemotherapy_regimen
- cBR96-Doxorubicin Immunoconjugate/Docetaxel [NCIt concept]
- cBR96-Doxorubicin Immunoconjugate/Gemcitabine [NCIt concept]

Keyword's position in hierarchy(ies) :

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