Preferred Label : Allogeneic GM-CSF-secreting Myeloma Vaccine;
NCIt synonyms : Allogeneic GVAX Myeloma Vaccine; Allogeneic GM-CSF-secreting Myeloma Vaccine; GVAX Allogeneic Myeloma Vaccine; Allogeneic GM-CSF-secreting Multiple Myeloma Vaccine; Allogeneic Myeloma Vaccine with GM-CSF-secreting K562 Cells;
NCIt definition : An allogeneic plasma cell myeloma vaccine consisting two multiple myeloma cell lines,
H929 and U266, admixed with GM-CSF-secreting K562 cells, with potential antineoplastic
and immunopotentiating activities. Upon administration, the secreted GM-CSF modulates
the proliferation and differentiation of a variety of hematopoietic progenitor cells,
with some specificity towards stimulation of leukocyte production, and may reverse
treatment-induced neutropenia. This agent also promotes antigen presentation, upregulates
antibody-dependent cellular cytotoxicity (ADCC), increases interleukin-2-mediated
lymphokine-activated killer cell (LAK) function and may augment host antitumoral immunity.
For safety, the myeloma cells are irradiated prior to vaccination.;
NCI Metathesaurus CUI : CL970289;
Origin ID : C161652;
UMLS CUI : C5205975;
Semantic type(s)
- concept_is_in_subset
