Preferred Label : Anti-SEZ6 Antibody-drug Conjugate ABBV-011;
NCIt synonyms : Anti-SEZ6 ADC ABBV-011;
NCIt definition : An antibody-drug conjugate (ADC) composed of a monoclonal antibody directed against
seizure protein 6 homolog (SEZ6) linked to the cytotoxic antitumor antibiotic calicheamicin,
with potential antineoplastic activity. Upon administration of anti-SEZ6 ADC ABBV-011,
the monoclonal antibody moiety targets and binds to SEZ6 expressed on tumor cells.
Upon binding and internalization, calicheamicin is released. Calicheamicin binds to
the minor groove of DNA, causing double strand DNA breaks and resulting in apoptosis
of SEZ6-expressing tumor cells. SEZ6, overexpressed in certain cancers while minimally
expressed in normal tissues, plays a role in cell-cell recognition and in neuronal
membrane signaling.;
Molecule name : ABBV-011; SC 011; ABBV 011; SC-011;
NCI Metathesaurus CUI : CL970130;
Origin ID : C161599;
UMLS CUI : C5205928;
Semantic type(s)
- concept_is_in_subset
- has_target
