Elinafide - CISMeF

Preferred Label : Elinafide;

NCIt synonyms : N,N'-(Trimethylenebis(iminoethylene))dinaphthalimide;

NCIt related terms : LU 79553;

NCIt definition : A symmetrical dimeric bis-naphthalimide compound and a topoisomerase II inhibitor with antineoplastic activity. Elinafide contains two neutral chromophores joined by a cationic linker and is capable of bis-intercalation at the TpG and CpA steps of the DNA hexanucleotide. Intercalation inhibits topoisomerase II activity and causing DNA stand breakage, thereby leads to inhibition of DNA, RNA, and protein synthesis.;

Alternative definition : NCI-GLOSS: An anticancer drug that kills cancer cells by affecting DNA synthesis.;

UNII : HL580335SI;

InChIKey : QUNOQBDEVTWCTA-UHFFFAOYSA-N;

CAS number : 162706-37-8;

Molecule name : LU 79553; LU-79553;

Chemical formula : C31H28N4O4;

Codes from synonyms : CDR0000045517;

Details

Origin ID

C1615;

UMLS CUI

C1433453;

Automatic exact mappings (from CISMeF team)
- LU 79553 [MeSH concept]
- elinafide [MeSH Supplementary Concept]
Currated CISMeF NLP mapping
- elinafide [MeSH concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- elinafide [MeSH concept]
- elinafide [MeSH Supplementary Concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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