KRN5500 - CISMeF

Preferred Label : KRN5500;

NCIt synonyms : 6-[4-Deoxy-4-[(2E,4E)-tetradecadienoylglycyl]amino-L-glycero-beta-L-mannohepto-pyranosyl]amino-9H-purine;

NCIt related terms : KRN-5500;

NCIt definition : A semisynthetic derivative of the nucleoside-like antineoplastic antibiotic spicamycin, originally isolated from the bacterium Streptomyces alanosinicus. KRN 5500 inhibits protein synthesis by interfering with endoplasmic reticulum and Golgi apparatus functions. This agent also induces cell differentiation and caspase-dependent apoptosis. (NCI04);

Alternative definition : NCI-GLOSS: An anticancer drug that belongs to a family of drugs called antitumor antibiotics. It is an anthracycline.;

UNII : 8VH13L5K20;

CAS number : 151276-95-8;

Molecule name : KRN5500;

NSC code : 650426;

Codes from synonyms : CDR0000045518; NSC0650426;

Details

Origin ID

C1614;

UMLS CUI

C0294829;

Automatic exact mappings (from CISMeF team)
- KRN 5500 [MeSH Supplementary Concept]
- KRN 5500 [MeSH concept]
Semantic type(s)
- Nucleic Acid, Nucleoside, or Nucleotide [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- KRN 5500 [MeSH Supplementary Concept]
- KRN 5500 [MeSH concept]
chemical_or_drug_affects_cell_type_or_tissue
- Endoplasmic Reticulum [NCIt concept]
- Golgi Apparatus [NCIt concept]
chemical_or_drug_has_mechanism_of_action
- Unknown Cellular or Molecular Mechanism [NCIt concept]
chemical_or_drug_has_physiologic_effect
- Cell Differentiation Process [NCIt concept]
- Positive Regulation of Apoptosis [NCIt concept]
- Translational Repression [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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