Antineoplaston AS2-1

Preferred Label : Antineoplaston AS2-1;

NCIt synonyms : L-Glutamine, N2-(phenylacetyl)-, Monosodium Salt, Mixture with Sodium Benzeneacetate; Astugenal; AS2-1;

NCIt definition : A 4:1 mixture of phenylacetate and phenylacetylgluatmine, degradation products of the antineoplaston agent A10. Antineoplaston AS2-1 inhibits the incorporation of L-glutamine into tumor-cell proteins, leading to cell cycle arrest in the G1 phase and inhibition of mitosis. This agent may also inhibit RAS oncogene expression and activate tumor suppressor gene p53, resulting in cell differentiation and apoptosis. (NCI04);

CAS number : 104624-98-8;

NSC code : 620261;

Codes from synonyms : NSC0620261;

Details

Origin ID

C1613;

UMLS CUI

C0294295;

Currated CISMeF NLP mapping
- antineoplaston AS 2-1 [MeSH concept]
- antineoplaston AS 2-1 [MeSH Supplementary Concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- antineoplaston AS 2-1 [MeSH concept]
- antineoplaston AS 2-1 [MeSH Supplementary Concept]
concept_is_in_subset
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
is_component_of_chemotherapy_regimen
- Antineoplaston A10/Antineoplaston AS2-1 [NCIt concept]

Keyword's position in hierarchy(ies) :

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