Preferred Label : Allogeneic CD25/Treg-depleted Donor Lymphocytes;
NCIt synonyms : CD25hi-depleted Donor Lymphocytes; Allogeneic Treg-depleted Donor Lymphocytes; CD25/Treg-depleted Donor Lymphocytes;
NCIt definition : A preparation of allogeneic peripheral blood mononuclear cells (PBMCs) derived from
an 8/8 HLA-matched donor that have been selectively depleted of CD4 CD25hiFoxp3 regulatory
T-cells (Tregs; CD25hi Tregs) with potential to enhance graft-versus-tumor (GVT) immune
responses in patients with myeloid relapse following a hematopoietic stem cell transplant
(HSCT) from a matched donor. Following collection and ex-vivo depletion of CD25hi
Tregs from PBMCs derived from the original donor, the CD25/Treg-depleted donor lymphocytes
are infused into the patient. Upon administration, the CD25/Treg-depleted donor lymphocyte
infusion (DLI) may enhance the proliferation of CD4 and CD8 effector T-cells (Teffs)
and potentially induce curative GVT immune responses in patients with myeloid relapse
following HSCT.;
NCI Metathesaurus CUI : CL969828;
Origin ID : C160729;
UMLS CUI : C5205502;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
