Preferred Label : PD-1 Directed Probody CX-188;
NCIt synonyms : CX 188; Anti-PD-1 Probody CX-188;
NCIt definition : A probody composed of a monoclonal antibody directed against the negative immunoregulatory
human cell surface receptor, programmed cell death protein 1 (PD-1; PDCD1; CD279),
linked to a proprietary masking peptide that covers the active antigen binding site
of the antibody through a protease-cleavable linker, with potential immune checkpoint
inhibitory and antineoplastic activities. Upon administration of PD-1-directed probody
CX-188, the masking peptide is cleaved by tumor-associated proteases within the tumor
microenvironment (TME). Protease-mediated removal of the linker enables binding of
the unmasked monoclonal antibody moiety to PD-1, thereby disrupting PD-1 signaling.
This may restore immune function through the activation of T-cells and T-cell-mediated
immune responses against tumor cells. PD-1, a transmembrane protein in the immunoglobulin
superfamily (IgSF) expressed on T-cells, functions as an immune checkpoint that negatively
regulates T-cell activation and effector function when activated by its ligands programmed
cell death-1 ligand 1 (PD-L1) or 2 (PD-L2); it plays an important role in tumor evasion
from host immunity. Tumor-associated proteases are present in high concentrations
and aberrantly activated in the TME.;
Molecule name : CX-188;
NCI Metathesaurus CUI : CL969825;
Origin ID : C160716;
UMLS CUI : C5205492;
Semantic type(s)
- concept_is_in_subset
- has_target
