Preferred Label : HDAC Class I/IIb Inhibitor HG146;
NCIt synonyms : Class I/IIb HDACi HG146; HDAC I/IIb Selective Inhibitor HG146; HG-146;
NCIt definition : An orally available inhibitor of histone deacetylase (HDAC) classes I and IIb with
potential antineoplastic activities. Upon oral administration, HDAC I/IIb inhibitor
HG146 selectively inhibits the catalytic activity of class I and IIb HDACs, which
results in an accumulation of highly acetylated chromatin histones, the induction
of chromatin remodeling and an altered pattern of gene expression. This leads to the
inhibition of tumor oncogene transcription, and the selective transcription of tumor
suppressor genes, which inhibits tumor cell division and induces tumor cell apoptosis.
HDAC, an enzyme upregulated in many tumor types, deacetylates chromatin histone proteins.
Class I HDACs are located in the nucleus and include HDACs 1, 2, 3, and 8; class IIb
HDACs include HDAC 6 and 10 and are located in both the nucleus and the cytoplasm.;
Molecule name : HG 146; HG280146-P1; HG280146; HG146; HG0146;
NCI Metathesaurus CUI : CL969804;
Origin ID : C160706;
UMLS CUI : C5205482;
Semantic type(s)
- concept_is_in_subset
