Preferred Label : Allogeneic CD34 -enriched and CD45RA-depleted PBSCs;
NCIt synonyms : Donor-derived Tn Cell Depleted CD34-enriched PBSCs; Allogeneic TnD- CD34 PBSCs; Allogeneic Tn-depleted CD34-preserved PBSCs; Naive T-cell Depleted CD34 Allogeneic Peripheral Blood Stem Cells;
NCIt definition : A preparation of donor-derived peripheral blood stem cells (PBSCs) that have been
enriched with CD34-positive stem cells and have been depleted of CD45RA-positive cells,
that can potentially be used for immune reconstitution purposes. CD45RA depletion
results in a cellular product that contains a high amount of memory T-cells (Tm).
Upon infusion of the allogeneic CD34 -enriched and CD45RA-depleted PBSCs after a hematopoietic
cell transplantation (HCT), these cells provide Tm recovery and are able to prevent
viral infections. The depletion of the CD45RA-positive cells reduces the risk of graft-versus-host
disease (GvHD) upon infusion. CD45RA is expressed on naive T-cells (Tn), whereas Tm
cells are CD45RA-negative. Tn cells have the potential to induce more severe GvHD
than Tm cells.;
NCI Metathesaurus CUI : CL969675;
Origin ID : C160621;
UMLS CUI : C5205406;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
