Tallimustine - CISMeF

Preferred Label : Tallimustine;

NCIt definition : A benzoyl mustard derivative of the antiviral agent distamycin A with potential antineoplastic activity. Tallimustine selectively binds to A-T rich regions in the minor groove of DNA and alkylates at the N3 position of adenine in a highly sequence-specific manner. This prevents DNA replication, inhibits cellular proliferation and triggers apoptosis. Moreover, unlike other clinical nitrogen mustards, tallimustine does not carry out guanine-N7 alkylation in the major groove of DNA, which may lead to a high selectivity of action.;

UNII : 71193OXG6S;

InChIKey : ARKYUICTMUZVEW-UHFFFAOYSA-N;

CAS number : 115308-98-0; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 115308-98-0 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Molecule name : FCE 24517; PNU-152241;

Chemical formula : C32H38Cl2N10O4;

Details

Origin ID

C1603;

UMLS CUI

C0286890;

Currated CISMeF NLP mapping
- tallimustine [MeSH concept]
- tallimustine [MeSH Supplementary Concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- tallimustine [MeSH Supplementary Concept]
- tallimustine [MeSH concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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