Preferred Label : Enterococcus gallinarum Strain MRx0518;
NCIt synonyms : Gut Microbiota-derived Strain MRx0518; E. gallinarum MRx0518;
NCIt definition : A live strain of the flagellin-producing Gram-positive bacterium Enterococcus (E.)
gallinarum that is isolated from a healthy human gut, with potential immunomodulating
and antineoplastic activities. Upon oral administration, MRx0518 modulates the intestinal
microbiota and targets both intestinal epithelial cells (IECs), and various immune
cells, such as macrophages and dendritic cells (DCs) and is able to induce the production
of both pro- and anti-inflammatory mediators, such as interleukin-8 (IL-8), tumor
necrosis factor-alpha (TNF-a), IL-1beta, IL-6, IL-23, in these cells and activates
the innate immune system. The flagellin produced by MRx0518 interacts with and activates
toll-like receptor 5 (TLR5), thereby activating the adaptive immune system and modulating
the tumor microenvironment (TME). This activates the immune system to mount a cytotoxic
T-lymphocyte (CTL) immune response against tumor cells.;
Molecule name : MRx 0518; MRx-0518;
NCI Metathesaurus CUI : CL969238;
Origin ID : C160293;
UMLS CUI : C5205116;
Semantic type(s)
- concept_is_in_subset
