Preferred Label : Amredobresib;
NCIt synonyms : BET inhibitor BI 894999; 1,2,4-Triazolo(4,3-a)pyrazin-8-amine, N,3-dimethyl-6-(6-(4-methyl-1-piperazinyl)-1-(phenylmethyl)-1hbenzimidazol-2-yl); 6-(1-Benzyl-6-(4-methylpiperazin-1-yl)-1H-1,3-benzodiazol-2-yl)-N,3-dimethyl-(1,2,4)triazolo(4,3-a)pyrazin-8-amine;
NCIt definition : An orally bioavailable inhibitor of the bromodomain and extra-terminal (BET) family
of proteins with potential antineoplastic activity. Upon oral administration, amredobresib
binds to bromodomain-containing proteins 2, 3, and 4 (BRD2, BRD3, and BRD4) as well
as bromodomain testis-specific protein (BRDT), thereby preventing the interaction
between BET proteins and acetylated histones. This disrupts chromatin remodeling and
suppresses the expression of certain oncogenes, including Myc and other transcriptional
regulators. Preventing the expression of certain growth-promoting genes may lead to
an inhibition of tumor cell growth. Characterized by a tandem repeat of bromodomains
at the N-terminus, BET proteins, comprised of BRD2, BRD3, BRD4 and BRDT, are transcriptional
regulators that play an important role during cellular development and growth.;
UNII : F6XR3O34V2;
CAS number : 1610044-98-8;
Molecule name : BI-894999; BI 894999;
NCI Metathesaurus CUI : CL969271;
Origin ID : C160257;
UMLS CUI : C5706573;
Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
- has_target
