Preferred Label : CALR Exon 9 Mutant Peptide Vaccine/Montanide ISA-51;
NCIt synonyms : CALR Exon 9 Mutant Peptide Vaccine With Montanide ISA-51; CALRLong36 Peptide Vaccine/Montanide ISA-51;
NCIt definition : A peptide vaccine consisting of a calreticulin (CALR) mutant peptide, CALRLong36,
and montanide ISA 51 with potential antineoplastic activity. Upon vaccination, the
CALR exon 9 mutant peptide vaccine may stimulate the host immune system to mount a
cytotoxic T-lymphocyte (CTL)-mediated response against tumor cells harboring mutations
in exon 9 of the calreticulin gene. CALR, an endoplasmic reticulum chaperone protein
that normally facilitates protein folding, immune response, and hematopoiesis, is
often mutated in patients with chronic myeloproliferative neoplasms. In its mutant
form, CALR is secreted into the plasma, where it binds to and activates the thrombopoietin
receptor MPL and initiates downstream JAK/STAT signaling. Montanide ISA-51, also known
as incomplete Freund's adjuvant or IFA, is a stabilized water-in-oil (w/o) emulsion
adjuvant containing mineral oil with mannide oleate added as a surfactant that non-specifically
stimulates cell-mediated immune responses to antigens.;
NCI Metathesaurus CUI : CL969340;
Origin ID : C160197;
UMLS CUI : C5205028;
Semantic type(s)
- concept_is_in_subset
