Preferred Label : Tezemlimogene Daxadenorepvec;
NCIt synonyms : Oncolytic Adenovirus Armed With OX40L DNX-2440; OX40L-expressing Oncolytic Adenovirus DNX-2440;
NCIt definition : A selectively replication competent oncolytic adenovirus that is engineered to express
OX40 ligand (OX40L) with potential oncolytic and immunostimulatory activities. Upon
administration, tezemlimogene daxadenorepvec, which contains an integrin binding RGD-4C
motif, infects tumor cells in a Coxsackievirus-adenovirus receptor-independent manner
and selectively replicates in tumor cells that are defective in retinoblastoma gene
(Rb) or cyclin-dependent kinase inhibitor-2A (p16). Tumor cell selectivity is achieved
through a 24-base pair deletion in the E1A gene, which renders the oncolytic adenovirus
unable to replicate in normal cells that maintain a functional Rb pathway, but fully
replication competent in Rb/p16 defective tumor cells. Active replication of the OX40L-expressing
oncolytic adenovirus within tumor cells may induce oncolysis and release of OX40L.
OX40L may then bind to and activate signaling pathways downstream of its cognate receptor,
tumor necrosis factor receptor superfamily member 4 (TNFRSF4; OX40), which is expressed
on activated T-cells. OX40L/OX40 binding promotes increased cytokine production, which
can induce proliferation of memory and effector T-lymphocytes and promote the killing
of nearby tumor cells. OX40L, a cell surface glycoprotein and member of the tumor
necrosis factor (TNF) ligand family, provides a co-stimulatory signal for the proliferation
and survival of activated T-cells. The Rb gene product and p16 are negative regulators
of the cell cycle and are defective in certain tumor types.;
UNII : B7N7BR6M4A;
CAS number : 2642046-11-3;
Molecule name : DNX-2440; DNX 2440;
NCI Metathesaurus CUI : CL969332;
Origin ID : C160192;
UMLS CUI : C5783376;
Semantic type(s)
- concept_is_in_subset
