Cidofovir - CISMeF

Preferred Label : Cidofovir;

NCIt synonyms : Cidofovir Dihydrate; 1(3-hydroxy-2-phosphonomethoxypropyl) Cytosine; HPMPC; CDV;

NCIt definition : A synthetic, acyclic, monophosphate nucleotide analog of deoxycytidine with antiviral activity, and mostly used against cytomegalovirus (CMV). After incorporation into the host cell, cidofovir is phosphorylated by pyruvate kinases to its active metabolite cidofovir diphosphate. Cidofovir diphosphate, bearing structural similarity to nucleotides, competes with deoxycytosine-5-triphosphate (dCTP) for viral DNA polymerase and gets incorporated into the growing viral DNA strands. As a result, it prevents further DNA polymerization and disrupts DNA replication of viruses.;

Alternative definition : NCI-GLOSS: A drug used to treat infection caused by viruses.;

UNII : JIL713Q00N;

InChIKey : FPKARFMSZDBYQF-ILKKLZGPSA-N;

CAS number : 149394-66-1; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 149394-66-1 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Drug name : Vistide;

Molecule name : GS-0504; DRG-0145;

Chemical formula : C8H14N3O6P.2H2O;

ChEBI ID : CHEBI:59495;

Codes from synonyms : CDR0000045509;

Details

Origin ID

C1600;

UMLS CUI

C0286079;

Currated CISMeF NLP mapping
- Cidofovir [MeSH Descriptor]
- Cidofovir [LOINC component]
- Cidofovir (substance) [SNOMED CT concept]
- cidofovir [MeSH concept]
See also inter- (CISMeF)
- Product containing cidofovir (medicinal product) [SNOMED CT concept]
Semantic type(s)
- Nucleic Acid, Nucleoside, or Nucleotide [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Cidofovir [MeSH Descriptor]
- Cidofovir [LOINC component]
- Cidofovir (substance) [SNOMED CT concept]
- Product containing cidofovir (medicinal product) [SNOMED CT concept]
- cidofovir [ATC Code]
- cidofovir [MeSH concept]
Validated automatic mappings to BTNT
- cidofovir [ATC Code]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
has_target
- DNA Polymerase [NCIt concept]

Keyword's position in hierarchy(ies) :

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