Preferred Label : Alpha/beta T-cell/CD19 B-cell-depleted Unrelated or Partially Matched Donor-derived
Allogeneic Peripheral Blood Stem Cells;
NCIt synonyms : Alpha/beta T-cell/CD19 B-cell-depleted Unrelated or Partially Matched Donor-derived
Allogeneic PBSCs; Alpha/beta T-cell and CD19 B-cell-depleted Allogeneic PBSCs Derived from an Unrelated
or Partially Matched Donor;
NCIt definition : A preparation of allogeneic peripheral blood stem cells (PBSCs) from an unrelated
or partially matched related donor that have been selectively depleted of alpha/beta
T-cells and CD19-positive (CD19 ) B-cells with potential immune reconstituting activity.
The alpha/beta T-cell/CD19 B-cell-depleted stem cells contain high amounts of natural
killer (NK) cells, gamma/delta T-cells, CD34 stem cells, and dendritic cells (DCs),
while devoid of alpha/beta T-cells and CD19-positive B-cells. Depletion of alpha/beta
T-cells, which are implicated in the adaptive immune response that mediates graft-versus-host
disease (GvHD), may promote rapid and sustained engraftment, immune reconstitution,
and may prevent or reduce the development of GvHD. The depletion of CD19 B-cells
may reduce the risk of Epstein-Barr virus (EBV)-driven post-transplant lymphoproliferative
disorders. The retained CD3 gamma/delta T-cells and NK cells may synergistically
exert an anti-leukemic and antiviral effector function, which may further promote
engraftment and immune reconstitution.;
NCI Metathesaurus CUI : CL969107;
Origin ID : C159940;
UMLS CUI : C5204815;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
