Preferred Label : [Leu15] Gastrin-17;
NCIt synonyms : GAST 17;
NCIt definition : A C-terminal amidated synthetic gastrin analog with a single amino acid change at
position 15, where leucine replaces methionine, with potential hypoglycemic and immunomodulatory
activities. Following pancreatic islet cell transplantation, subcutaneous administration
of [Leu15] Gastrin-17 (GAST-17) may induce pancreatic beta cell regeneration and expansion
and enhance the insulin secretory capacity of islet cell grafts. Additionally, GAST-17
may reduce inflammation within the islet cell environment, which could potentially
improve islet graft survival and function. Gastrin, a gastrointestinal peptide, may
induce beta cell neogenesis via induction of the duodenal and pancreatic homeobox
transcription factor, PDX-1. Gastrin may also promote beta cell proliferation and
neogenesis indirectly through increasing the production of clustrin, a beta cell expansion
factor.;
Molecule name : GAST-17;
NCI Metathesaurus CUI : CL968999;
Origin ID : C159822;
UMLS CUI : C5204720;
Semantic type(s)
concept_is_in_subset