Preferred Label : IMWG Progressive Disease;
NCIt synonyms : Progressive Disease;
NCIt definition : Any one or more of the following criteria: increase of 25 percent from lowest confirmed
response value in one or more of the following criteria: serum M-protein (absolute
increase must be at least 0.5 g/dL); serum M-protein increase at least 1 g/dL, if
the lowest M component was at least 5 g/dL; urine M-protein (absolute increase must
be at least 200 mg/24 h); in patients without measurable serum and urine M-protein
levels, the difference between involved and uninvolved free light chain levels (absolute
increase must be greater than 10 mg/dL); in patients without measurable serum and
urine M-protein levels and without measurable involved free light chain levels, bone
marrow plasma-cell percentage irrespective of baseline status (absolute increase must
be at least 10 percent); appearance of a new lesion(s), at least 50 percent increase
from nadir in sum of products of diameters of greater than 1 lesion, or at least 50
percent increase in the longest diameter of a previous lesion greater than 1 cm in
short axis; at least 50 percent increase in circulating plasma cells (minimum of 200
cells per uL) if this is the only measure of disease.;
NCI Metathesaurus CUI : CL951616;
Origin ID : C159811;
UMLS CUI : C5202991;
Automatic exact mappings (from CISMeF team)
- Semantic type(s)
