Preferred Label : Tasadenoturev-infected Allogeneic Bone Marrow-derived Mesenchymal Stem Cells;
NCIt synonyms : Allogeneic BM-hMSC-D24; BM-hMSC-Delta-24-RGD; BM-hMSC-D24; Allogeneic BM-hMSC-Delta-24-RGD; Allogeneic Bone Marrow Mesenchymal Stem Cells Loaded with Oncolytic Adenovirus DNX-2401; Ad5-DNX-2401-infected Allogeneic Bone Marrow Mesenchymal Stem Cells; Allogeneic Bone Marrow Mesenchymal Stem Cells loaded with Tasadenoturev; Allogeneic Bone Marrow Mesenchymal Stem Cells loaded with DNX-2401; Ad5-DNX-2401-infected Allogeneic Bone Marrow MSCs; Oncolytic Adenovirus Ad5-DNX-2401-infected Allogeneic Bone Marrow Mesenchymal Stem
Cells;
NCIt definition : A preparation of bone marrow-derived allogeneic mesenchymal stem cells (MSCs) infected
with tasadenoturev (Ad5-DNX-2401), an adenovirus serotype 5 strain that is selectively
replication competent in cells defective in the Rb/p16 tumor suppressor pathway, with
potential antineoplastic activity. Upon infusion of the tasadenoturev-infected bone
marrow-derived MSCs, these cells target and deliver the adenovirus to tumor cells.
The oncolytic virus then selectively transfects and replicates in the tumor cells,
eventually leading to tumor cell lysis and the release of virus particles and various
tumor associated antigens (TAAs). This may induce a systemic immune response against
tumor cells expressing these TAAs and further infection and killing of nearby tumor
cells by the released viral particles. Ad5-DNX-2401 contains an integrin binding RGD-4C
motif, allowing Coxsackievirus and adenovirus receptor-independent infection of tumor
cells, which are often deficient for Coxsackievirus and adenovirus receptors (CARs).
As integral components of the late G1 restriction point, the Rb gene product and p16
are negative regulators of the cell cycle and are often defective in certain cancer
types.;
NCI Metathesaurus CUI : CL951603;
Origin ID : C159798;
UMLS CUI : C5204705;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
