" /> Pacanalotamab - CISMeF





Preferred Label : Pacanalotamab;

NCIt synonyms : Anti-BCMA x Anti-CD3 BiTE AMG 420; BiTE Antibody AMG 420; Bispecific T-cell Engager Antibody AMG 420; BCMA/CD3-directed Bispecific T-cell Engager Antibody AMG 420; Anti-BCMA/CD3 BiTE Antibody AMG 420;

NCIt definition : A short half-life bispecific T-cell engager (BiTE) antibody composed of two single-chain variable fragments (scFv), one directed against the tumor-associated antigen (TAA) human B-cell maturation antigen (BCMA; TNFRSF17), fused to one that is directed against the CD3 antigen found on T-lymphocytes, with potential immunostimulating and antineoplastic activities. Upon administration of pacanalotamab, this bispecific antibody binds to both CD3 on cytotoxic T-lymphocytes (CTLs) and BCMA found on BCMA-expressing tumor cells. This activates and redirects CTLs to BCMA-expressing tumor cells, which results in the CTL-mediated cell death of BCMA-expressing tumor cells. BCMA, a member of the tumor necrosis factor receptor superfamily that is specifically overexpressed on malignant plasma cells, plays a key role in promoting plasma cell survival.;

UNII : 102VUR9WQE;

CAS number : 2251756-52-0;

Molecule name : AMG 420; AMG-420; BI-836909; BI 836909;

NCI Metathesaurus CUI : CL951538;

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24/05/2025


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