Preferred Label : Emicizumab;
NCIt synonyms : Immunoglobulin G4-kappa, Bispecific, Anti-(Homo sapiens F9a (Activated Coagulation
Factor F9, Activated Coagulation Factor IX) and Anti-(Homo sapiens F10 (Coagulation
Factor 10, Coagulation Factor X)), Humanized Monoclonal Antibody; Emicizumab-kxwh;
NCIt definition : A humanized, immunoglobulin G4 (IgG4), bispecific monoclonal antibody against both
the activated coagulation factor IX (FIXa) and factor X (FX) that can be used for
the treatment of hemophilia A (HA). Upon administration, emicizumab targets and binds
to both the FIXa and to FX, thereby bridging FIXa and FX, activating FX, and allowing
for the activation and continuation of the coagulation cascade. FX is normally activated
by coagulation factor VIII (FVIII); FVIII is missing in HA patients.;
UNII : 7NL2E3F6K3;
CAS number : 1610943-06-0;
Drug name : Hemlibra;
Molecule name : ACE-910; ACE 910;
Codes from synonyms : 181;
Origin ID : C159541;
UMLS CUI : C4278463;
Automatic exact mappings (from CISMeF team)
- Currated CISMeF NLP mapping
- See also inter- (CISMeF)
- Semantic type(s)
- UMLS correspondences (same concept)
- Validated automatic mappings to BTNT
- chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
