Preferred Label : Radium Ra 224-labeled Calcium Carbonate Microparticles;
NCIt synonyms : 224Ra-labeled Calcium Carbonate Micro-particles; Ra-224 Alpha-emitting Calcium Carbonate Microparticles; Alpha-emitting 224Ra Calcium Carbonate Microspheres;
NCIt definition : A radiopharmaceutical composed of biodegradable calcium carbonate microspheres labeled
with the alpha-emitting radioisotope radium Ra 224, with antineoplastic activity.
Upon intraperitoneal (IP) administration of the radium Ra 224-labeled calcium carbonate
microparticles, Ra 224 kills tumor cells through local emission of high energy alpha
particles, causing DNA double-strand breaks. The short range effects of alpha emission
allows for localized DNA damage with limited toxicity to nearby healthy tissue.;
Drug name : Radspherin;
NCI Metathesaurus CUI : CL951431;
Origin ID : C159537;
UMLS CUI : C5204511;
Semantic type(s)
- concept_is_in_subset
