Preferred Label : PI3K/mTOR Kinase Inhibitor WXFL10030390;
NCIt synonyms : PI3K/mTOR Kinase Inhibitor WX390; WX-390; WXFL-10030390;
NCIt definition : An orally bioavailable, small molecule inhibitor of certain phosphoinositide 3-kinase
(PI3K) isoforms and mammalian target of rapamycin kinase (mTOR) in the PI3K/mTOR signaling
pathway, with potential antineoplastic activity. Upon oral administration, PI3K/mTOR
inhibitor WXFL10030390 (WX390) inhibits mTOR kinase and certain PI3K isoforms. Consequently,
this disrupts phosphorylation of substrates downstream of PI3K and mTOR and may result
in apoptosis and growth inhibition in susceptible tumor cells. The PI3K/mTOR pathway
is upregulated in a variety of tumor cells and plays a key role in promoting cancer
cell proliferation, and survival, motility and resistance to chemotherapy and radiotherapy.
mTOR, a serine/threonine kinase downstream of PI3K, may also be activated in a PI3K-independent
fashion; therefore, this agent may be more potent than an agent that inhibits either
PI3K or mTOR alone.;
Molecule name : WXFL10030390; WX390; WX 390; WXFL 10030390;
NCI Metathesaurus CUI : CL951457;
Origin ID : C159499;
UMLS CUI : C5204487;
Semantic type(s)
- concept_is_in_subset
