Preferred Label : IDO Peptide Vaccine IO102;
NCIt synonyms : IO-102; Indoleamine 2,3-dioxygenase-derived Peptide Vaccine; IDO-derived Vaccine IO102;
NCIt definition : A second-generation peptide vaccine derived from the immunomodulatory enzyme indoleamine
2,3-dioxygenase (IDO) with potential immunomodulating and antineoplastic activities.
Vaccination with IDO peptide vaccine IO102 may activate the immune system to induce
an immune response against IDO-expressing tumor cells. This may restore the proliferation
and activation of various immune cells including cytotoxic T-lymphocytes (CTLs), natural
killer cells (NKs), and dendritic cells (DCs), and may eradicate IDO-expressing tumor
cells through a CTL-mediated response. IDO, a cytosolic enzyme responsible for tryptophan
catabolism and conversion of tryptophan into kynurenine, is overexpressed by a variety
of tumor cell types and antigen presenting cells (APCs) and plays an important role
in immunosuppression mainly through suppression of CTL activation.;
Molecule name : IO 102; IO102;
NCI Metathesaurus CUI : CL951456;
Origin ID : C159498;
UMLS CUI : C5204486;
Semantic type(s)
- chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
