Preferred Label : Alpha-lactalbumin-derived Synthetic Peptide-lipid Complex Alpha1H;
NCIt synonyms : Alpha-lactalbumin-derived Synthetic Proteolipid Complex Alpha1H;
NCIt definition : A synthetic proteolipid complex comprised of the alpha-1 domain of alpha-lactalbumin
(lactose synthase B protein) and oleic acid, with potential antineoplastic activity.
Upon intravesical instillation, alpha1H selectively accumulates in the nuclei of tumor
cells and binds to histones H3, H4, and H2B. By binding to histones, alpha1H disrupts
chromatin assembly and interferes with intact chromatin, thereby preventing tumor
cell transcription and replication. Additionally, alpha1H inhibits the phosphorylation
of multiple kinases involved in cancer-associated pathways including the Ras/Raf/ERK,
PI3K/AKT, p38 MAPK and JNK signaling pathways. This may inhibit tumor cell proliferation
and induce apoptosis in tumor cells that are driven by the dysregulation of certain
kinases and oncogenic GTPases.;
Molecule name : Alpha 1H; Alpha-1H;
NCI Metathesaurus CUI : CL951455;
Origin ID : C159497;
UMLS CUI : C5204485;
Semantic type(s)
- concept_is_in_subset
