EBNA-1 inhibitor VK-2019

Preferred Label : EBNA-1 inhibitor VK-2019;

NCIt synonyms : Epstein-Barr Nuclear Antigen 1 Inhibitor VK-2019;

NCIt definition : An orally available, small molecule inhibitor of Epstein-Barr nuclear antigen 1 (EBNA-1) with potential antineoplastic activity. Upon administration, EBNA-1 inhibitor VK-2019 binds to EBNA-1 and inhibits EBNA-1 DNA binding activity. This disrupts the replication, maintenance and segregation of the Epstein-Barr virus (EBV) genome, which may lead to tumor cell death in EBV-associated malignancies. EBNA1, a sequence-specific DNA binding protein, plays an important role in EBV episomal genome maintenance and gene transactivation.;

Molecule name : VK 2019; VK-2019;

NCI Metathesaurus CUI : CL951268;

Details

Origin ID

C159410;

UMLS CUI

C5204408;

Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Epstein-Barr Nuclear Antigen 1 [NCIt concept]

Keyword's position in hierarchy(ies) :

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