Preferred Label : Botulinum Toxin E EB-001;
NCIt synonyms : BoNT/E EB-001; Botulinum Type E EB-001;
NCIt related terms : BOTULINUM TOXIN TYPE E;
NCIt definition : An injectable formulation containing the bacterial Clostridium botulinum type E neurotoxin,
with neuromuscular transmission inhibitory and analgesic activities. Upon injection
of botulinum toxin E EB-001 into the muscles of the affected area, the heavy chain
portion of botulinum toxin type E binds to the cell membrane of the presynaptic nerve
terminal and is internalized via endocytosis. Upon entry into the cytoplasm, the light
chain portion of the toxin binds to and cleaves synaptosomal-associated protein 25
(SNAP-25), thereby preventing the fusion of acetylcholine (ACh)-containing synaptic
vesicles with the cell membrane and, thus the release of the neurotransmitter ACh
into the neuromuscular junction. This prevents the binding of ACh to the motor end-plate
nicotinic acid receptors and ACh-mediated muscle contraction. This causes flaccid
paralysis and may decrease musculoskeletal pain and may improve wound healing and
reduce scar formation due to the absence of muscle contractions. In addition, EB-001
may inhibit the release of neuropeptides, such as substance P and glutamate, which
may contribute to its analgesic activity. Compared to other botulinum toxin types,
type E has the fastest onset and the shortest duration of action.;
UNII : T579M564JY;
Molecule name : EB-001; EB 001;
NCI Metathesaurus CUI : CL951324;
Origin ID : C159407;
UMLS CUI : C5204405;
Semantic type(s)
concept_is_in_subset