Preferred Label : Recombinant Chemokine;
NCIt synonyms : Chemokines; Therapeutic Chemokine;
NCIt definition : Formulated therapeutic analogs of one of a number of endogenous small polypeptide
cytokines with potential antineoplastic activity. Synthesized by macrophages, endothelial
cells, keratinocytes, fibroblasts, and smooth muscle cells, chemokines are released
in the presence of infection or physical tissue damage, and act as chemoattractants
to recruit macrophages, neutrophils, and T cells from the blood to sites of infection
or damage. These agents may regulate tumor growth by modulating tumor-associated angiogenesis
and metastasis and can either promote or retard tumor growth. (NCI04);
Origin ID : C1593;
UMLS CUI : C1527036;
Automatic exact mappings (from CISMeF team)
- chemokine [Blood Transfusion thesaurus concept]
- Currated CISMeF NLP mapping
- Semantic type(s)
