Preferred Label : Carbon C 11 Martinostat;
NCIt synonyms : [11C]Martinostat;
NCIt related terms : MARTINOSTAT C-11;
NCIt definition : A radioconjugate composed of martinostat, a histone deacetylase (HDAC) inhibitor,
labeled with the positron-emitting isotope carbon C 11, with potential use in imaging
via positron emission tomography (PET)/magnetic resonance imaging (MRI). Upon intravenous
administration of carbon C 11 martinostat, the martinostat moiety targets and binds
to HDAC on tumor cells. Upon PET/MRI imaging, this radioligand may allow for the assessment
of HDAC-expressing tumor cells. HDACs, upregulated in many tumor cell types, are a
family of metalloenzymes responsible for the deacetylation of chromatin histone proteins.;
UNII : 7LBT5K33WN;
InChIKey : WNIDBXBLQFPAJA-WKEKCCTESA-N;
CAS number : 1629052-59-0;
NCI Metathesaurus CUI : CL951030;
Origin ID : C159158;
UMLS CUI : C4279890;
Currated CISMeF NLP mapping
- Semantic type(s)
- concept_is_in_subset
