Actinium Ac 225-FPI-1434

Preferred Label : Actinium Ac 225-FPI-1434;

NCIt synonyms : [225Ac]-FPI-1434; Actinium Ac 225-labeled FPI-1434; Actinium Ac 225 Lintuzumab; [Ac-225]-FPI-1434; 225Ac-FPI-1434; Actinium Ac 225-FPI-1397-FPI-1175;

NCIt definition : A radioimmunoconjugate consisting of the humanized monoclonal antibody lintuzumab conjugated to the alpha-emitting radioisotope actinium Ac 225 with potential antineoplastic activity. The monoclonal antibody moiety of actinium Ac 225 lintuzumab specifically binds to the cell surface antigen CD33 antigen, delivering a cytotoxic dose of alpha radiation to cells expressing CD33. CD33 is a cell surface antigen expressed on normal non-pluripotent hematopoietic stem cells and overexpressed on myeloid leukemia cells.;

Molecule name : FPX-01; FPX 01;

NCI Metathesaurus CUI : CL950887;

Details

Origin ID

C158815;

UMLS CUI

C5203990;

Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Myeloid Cell Surface Antigen CD33 [NCIt concept]

Keyword's position in hierarchy(ies) :

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