Preferred Label : Actinium Ac 225-FPI-1434;
NCIt synonyms : [225Ac]-FPI-1434; Actinium Ac 225-labeled FPI-1434; Actinium Ac 225 Lintuzumab; [Ac-225]-FPI-1434; 225Ac-FPI-1434; Actinium Ac 225-FPI-1397-FPI-1175;
NCIt definition : A radioconjugate consisting of veligrotug, a humanized monoclonal antibody directed
against insulin-like growth factor-1 receptor (IGF-1R) linked, via a bifunctional
chelate, to the alpha-emitting radioisotope actinium Ac 225, with potential antineoplastic
activity. Upon administration of actinium Ac 225-FPI-1434, the veligrotug moiety targets
and binds to IGF-1R expressed on tumor cells. Upon binding, the radioisotope moiety
delivers a cytotoxic dose of alpha radiation to IGF-1R-expressing tumor cells. Activation
of IGF-1R, a receptor tyrosine kinase of the insulin receptor superfamily overexpressed
by various cancer cell types, stimulates cell proliferation, promotes angiogenesis,
enables oncogenic transformation, and suppresses apoptosis.;
Molecule name : FPX-01; FPX 01; FPI 1434; FPI-1434;
NCI Metathesaurus CUI : CL950887;
Origin ID : C158815;
UMLS CUI : C5203990;
Semantic type(s)
- concept_is_in_subset
- has_target
