Preferred Label : Barecetamab;
NCIt synonyms : Anti-HER3 Antibody ISU104; ISU-104; ISU104; Anti-ErbB3 Antibody ISU104;
NCIt definition : A fully human antibody directed against the receptor tyrosine-protein kinase erbB-3
(ErbB3; HER3) with potential antineoplastic activity. Upon intravenous administration,
barecetamab targets and binds to domain 3 and weakly interacts with domain 1 of ErbB3.
This prevents heregulin (HRG) binding and blocks dimerization of ErbB3, thereby inactivating
ErbB3 downstream signaling. ISU104 may also elicit the internalization of ErbB3 from
the plasma membrane and downregulate ErbB3 expression. This inhibits cellular proliferation
and survival of ErbB3-expressing tumor cells. ErbB3, a member of the epidermal growth
factor receptor (EGFR) family of receptor tyrosine kinases, is frequently overexpressed
in a variety of tumors and its overexpression generally correlates with poor prognosis
and tumor resistance.;
UNII : M9SE4M9U1V;
CAS number : 2275727-74-5;
Molecule name : ISU 104;
NCI Metathesaurus CUI : CL950712;
Origin ID : C158746;
UMLS CUI : C5446340;
Semantic type(s)
- chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
