NCIt definition : An ophthalmic nanoemulsion consisting of the tartrate salt form of brimonidine, an
imidazole derivative and selective alpha-2 adrenergic receptor agonist, with potential
anti-inflammatory and vasoconstrictive activities. Upon ophthalmic instillation, brimonidine
tartrate nanoemulsion OCU-300 reduces intraocular pressure by promoting the outflow
and decreasing the production of aqueous humor and may reduce ocular erythema through
direct vasoconstriction. Additionally, brimonidine may disrupt leukocyte extravasation
into the ocular tissue, inhibit nociception and reduce inflammation associated with
ocular graft-versus-host disease (oGvHD). The nanoemulsion formulation may enhance
distribution of brimonidine to target tissues, thereby allowing more of the active
drug to reach underlying ocular tissue.;
Semantic type(s)