Preferred Label : Neoantigen-based Renal Cell Carcinoma-Poly-ICLC Vaccine;
NCIt synonyms : NeoVax RCC Vaccine; NeoVax Renal Cell Carcinoma Vaccine;
NCIt definition : A peptide-based renal cell carcinoma (RCC) vaccine consisting of neoantigens and peptides
derived from immunogenic epitopes identified through DNA and RNA sequencing of a patient's
tumor cells, combined with the immunostimulant poly-ICLC with potential immunomodulating
and antineoplastic activities. Vaccination with the neoantigen-based RCC vaccine stimulates
the host immune system to mount a cytotoxic T-lymphocyte (CTL) response against tumor
cells expressing the neoantigens, leading to tumor cell lysis. The adjuvant poly-ICLC,
composed of double-stranded RNA molecules of polyinosinic-polycytidylic acid stabilized
with poly L-lysine in carboxymethylcellulose, is a ligand for toll-like receptor-3
(TLR3) and induces the release of cytokines which may help to boost the immune response
against the selected neoantigens.;
NCI Metathesaurus CUI : CL950784;
Origin ID : C158694;
UMLS CUI : C5203892;
Semantic type(s)
- concept_is_in_subset
