Preferred Label : Iodine I 124 Monoclonal Antibody M5A;
NCIt synonyms : Iodine I 124 Anti-CEA Monoclonal Antibody M5A; 124I-M5A; Iodine I 124 Monoclonal Antibody hT84.66-M5A; 124I-hT84.66-M5A; Iodine I 124 Anti-CEA Monoclonal Antibody hT84.66-M5A;
NCIt definition : A radioimmunoconjugate comprised of M5A, a humanized monoclonal antibody directed
against carcinoembryonic antigen-related cell adhesion molecule 5 (CEA or CEACAM5),
labeled with iodine I 124 (I-124) with potential radiolocalization applications. Upon
administration, the antibody moiety of iodine I 124 monoclonal antibody M5A specifically
binds to cells expressing CEA. Upon binding, the radioisotope moiety can be detected
using positron-emission tomography (PET), thereby allowing the imaging and quantification
of CEA-expressing tumor cells. CEA, a tumor associated antigen and a member of the
CEA family of proteins, plays a key role in cell migration, cell invasion, and cell
adhesion and is overexpressed by a variety of cancer types.;
NCI Metathesaurus CUI : CL950662;
Origin ID : C158629;
UMLS CUI : C5203831;
Semantic type(s)
- concept_is_in_subset
- has_target
